Golsamin

1. Notes and recommendations when using the drug:

• Read the directions carefully before use
• Keep out of reach of CHILDREN
• Immediately notify doctors or pharmacists of unwanted effects encountered when using the drug

2. Composition:

Each gram of the emulsion contains:

• Active ingredients: Methyl salicylate 300 mg, menthol 80 mg
• Excipients: PEG-100 stearate, glycerin, castor oil, propylene glycol, alcohol 96°, span 80, tween 80, stearic acid, disodium EDTA, propyl paraben, methyl paraben, sodium citrate, distilled water.

Pharmaceutical form: Emulsion for topical application

3. Pharmaceutical form:

Emulsion for topical application

4. Indications:

• Symptomatic treatment of pain of muscle-tendon origin.
• Pain due to arthritis, arthritis, bruises.
• Backache or stiff shoulder pain at work.
• Joint pain in the knees, hands, and ankles.
• Muscle pain and fatigue after physical activity or in the elderly.

5. Usage, dosage:

• Apply an adequate amount of emulsion, gently on the painful area.
• Rub sufficiently on the skin.
• Depending on needs, can apply Golsamin lotion several times (4-5 times) a day.
• Warning for Children and Children Over 7 Years: Need to wash hands clean after applying medicine.

6. Contraindications:

Golsamin lotion is contraindicated in cases of hypersensitivity to any ingredient of the drug.

• Do not apply to wounds and areas with infection such as swelling, heat, redness, or pain because hot essential oils dilate blood vessels, causing blood flow to the inflamed symptomatic area. As a result, inflammation and swelling become more.
• Do not apply to open wounds.
• Do not use for children under 3 years.
• Children with a history of seizures.
• Do not apply to mucous membranes, eyes, under eyes.

7. Warnings and caution when taking the drug:

• The drug contains the excipients propylene glycol, alcohol 96°, so be careful when using the drug because propylene glycol, alcohol 96° can cause skin irritation in patients with sensitive skin.
• The drug contains the excipients methyl paraben, propyl paraben, so be careful when using the drug because methyl paraben, propyl paraben can cause delayed allergic reactions.
• The drug contains castor oil, so be careful when using the drug because castor oil can cause skin reactions and the terpenic component in castor oil may increase the risk of seizures in the elderly.

8. Pregnancy and lactation:

No evidence is available as to the safety of the product when used during pregnancy and lactation, so the use of the product during pregnancy and lactation is not recommended.

9. Effects on ability to drive and use machines:

The drug does not affect the ability to drive and use machines.

10. Interaction with other medicinal products and other forms of interaction:

• When used in high doses, the drug can be absorbed into the bloodstream and may interact with anticoagulants such as acenocoumarol, warfarin, sodium warfarin, potassium warfarin, fluindion, phenylindion, which increase the risk of bleeding due to the effects of methyl salicylates on blood clotting. Therefore, this combination should be avoided, if the patient is taking these two drugs simultaneously, caution and close supervision are required.

11. Undesirable effects:

• The drug can cause atopic dermatitis, skin irritation.
• Drugs can increase the risk of seizures, seizures, and drowsiness in the elderly.

12. Overdose and treatment:

• There have been no reports of symptoms occurring when taking the recommended drug overdose, but if a large amount is rancid too many times a day, it can also cause skin irritation phenomena.
• Treatment: When taking the drug in excess of the recommended dose, the next dose should be used at the recommended dose. And when overdose phenomena appear, the drug should be stopped immediately, the phenomena will go away on their own when stopping the drug.

13. Pharmacodynamic properties:

Pharmacological group: Analgesic group against musculoskeletal inflammation
ATC code: MOZAx

Golsamin is a combination of methyl salicylate and menthol.

• Methyl salicylate is a nonsteroidal anti-inflammatory drug (NSAID) that is mainly used in the form of topical creams, massage oils, or patches. Methyl salicylate inhibits the synthesis of Prostaglandin E2, thus reducing the sensory properties of the sensory tips to the pain. Methyl salicylate inhibits pain, histamine, serotonin. The analgesic effects of methyl salicylates are closely related to their inflammatory pathogenesis such as bradykinin, histamine, and serotonin. The action of salicylates, causing dilation of the skin vessels. Methyl salicylate has local anti-inflammatory effects.
• Menthol has a cooling effect, which inhibits pain receptors. Menthol relieves itching, dilates the vessels causing a sensation of coldness followed by an analgesic effect. When combined with methyl salicylate, menthol increases the blood conductivity of methyl salicylate as well as the effects of methyl salicylate.

14. Pharmacokinetic properties:

After applying Golsamin lotion to the skin, active ingredients as methyl salicylate and menthol will be partially absorbed through the skin and enter the general circulation system. According to a new study after applying the active ingredients to the skin of volunteers, concentrations of menthol and methyl salicylate could only be measured with a large amount of the dressing. The half-lives of menthol and methyl salicylate are 5.6 ± 1.6 h and 3.0 ± 1.2 h, respectively. Methyl salicylate after being absorbed will be excreted by the kidneys and appear in the urine after 8 hours.

15. Packing specifications:

Box of 1 tube 50ml; Box of 1 tube 100ml